April 17, 2021 at Chicago Fire FC
April 24, 2021 vs. D.C. United
May 1, 2021 vs. Atlanta United FC
May 8, 2021 at Nashville SC
May 12, 2021 at Philadelphia Union
May 16, 2021 vs. Columbus Crew
May 22, 2021 vs. New York Red Bulls
May 29, 2021 at FC Cincinnati
June 19 at New York City FC
June 23 vs. New York Red Bulls
June 27 at FC Dallas
July 3 at Columbus Crew
July 7 vs. Toronto FC
July 25 vs. CF Montreal
July 31 at New York Red Bulls
August 4 vs. Nashville SC
August 8 vs. Philadelphia Union
August 14 at Toronto F
August 18 vs. D.C. United
August 28 at New York City FC
September 3 at Philadelphia Union
September 11 vs. New York City FC
September 18 vs. Columbus Crew
September 22 at Chicago Fire FC
September 25 vs. Orlando City SC
September 29 at CF Montreal
October 16 vs. Chicago Fire FC
October 20 at D.C. United
October 24 at Orlando City SC
October 27 vs. Colorado Rapids
November 7 vs. Inter Miami CF
Eastern Conference Semifinals vs. New York City FC