February 26, 2022 at Portland Timbers
March 5, 2022 vs. FC Dallas
March 9 vs. Pumas UNAM (SCCL Quarterfinals Leg 1)
March 12 vs. Real Salt Lake
March 16 at Pumas UNAM (SCCL Quarterfinals Leg 2)
March 19 at Charlotte FC
April 2 vs. New York Red Bulls
April 9 at Inter Miami CF
April 16 vs. Charlotte FC
April 23 at D.C. United
April 30 vs. Inter Miami CF
May 7 vs. Columbus Crew
May 11 vs. FC Cincinnati (U.S. Open Cup Round of 32)
May 15 at Atlanta United FC
May 21 at FC Cincinnati
May 25 at New York City FC (U.S. Open Cup Round of 16)
May 28 vs. Philadelphia Union
June 12 at Sporting Kansas City
June 15 vs. Orlando City SC
June 19 vs. Minnesota United FC
June 26 at Vancouver Whitecaps FC
July 3 vs. FC Cincinnati
July 9 at New York City FC
July 16 at Philadelphia Union
July 23 at Columbus Crew
July 30 vs. Toronto FC
August 6 at Orlando City SC
August 13 vs. D.C. United
August 17 at Toronto FC
August 20 at CF Montreal
August 28 vs. LA Galaxy
August 31 vs. Chicago Fire FC
September 4 vs. New York City FC
September 10 at New York Red Bulls
September 13 at Houston Dynamo FC
September 17 vs. CF Montreal